TAK-438 paura (1260141-27-2) paura - Kaihanga Kaihoko Kaihoko
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TAK-438

whakatauranga: Kāwai:

Ko te TAK438, e mohiotia ana ko Vonoprazan Fumarate, he rongoa hou hei whakaora i nga mate e pa ana ki te waikawa me te tikanga hou mo te mahi e kiia nei he poraka waikawa potassium-whakataetae (P-CABs) e aukati ana i te here o nga katote pāhare pāporo ki te H +, K + -ATPase ( e mohiotia ana ko te papu proton) i te waahanga whakamutunga o te waikawa waikawa haumanu i nga waahanga parietal puku, ka whakahaere i te waikawa waikawa haurangi. Ka whakarato i te kaha kaha o te aukati i te aukati i te aukati.

Whakaahuatanga Hua

Tikanga Matua

ingoa hua TAK-438 paura
CAS Tau 1260141-27-2
Tātai rāpoi C21H20FN3O6S
Taumaha Taumaha 461.46
Ngā Synonyms Vonoprazan Fumarate;
TAK-438 paura;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
ahua White ki te paura ma-paura
Te tiaki me te mahi Maroke, pouri me i te 0 - 4 C mo te wa poto (nga ra ki nga wiki) ko -20 C mo te wa roa (marama ki nga tau).

 

TAK-438 paura Whakaahuatanga

Ko te TAK438, e mohiotia ana ko Vonoprazan Fumarate, he rongoa hou hei whakaora i nga mate e pa ana ki te waikawa me te tikanga hou mo te mahi e kiia nei he poraka waikawa potassium-whakataetae (P-CABs) e aukati ana i te here o nga katote pāhare pāporo ki te H +, K + -ATPase ( e mohiotia ana ko te papu proton) i te waahanga whakamutunga o te waikawa waikawa haumanu i nga waahanga parietal puku, ka whakahaere i te waikawa waikawa haurangi. Ka whakarato i te kaha kaha o te aukati i te aukati i te aukati.

I roto i nga repe kopu kua maaka, na te rongoa puehu TAK-438 i hua ai te roa me te kaha o te aukati i te waihanga waikawa. Ko te aukati i te paura TAK-438 i runga i te hautanga waikawa i uru ki te taha o te haumanu poka rei parietal.

 

TAK-438 paura Tuhinga o te Mahi

Ko te paura TAK-438 (Vonoprazan fumarate) he pyrole i ahu mai me te kaiwhakatauta waikawa-whakataetae potassium (P-CAB) e aukati ana i te waahi-herea o te pāhare pāporo H (+), K (+) - ATPase, he whākōkī matua i roto i te tukanga o te waikawa waikawa puku. Ka taea e te kohinga te kohikohi i roto i nga taiao waikawa me te whakarato i te roa o te aukati na te pKa kawakore o te 9.06.

I roto i nga repe kopu kua maaka, na te rongoa puehu TAK-438 i hua ai te roa me te kaha o te aukati i te waihanga waikawa. Ko te aukati i te paura TAK-438 i runga i te hautanga waikawa i uru ki te taha o te haumanu poka rei parietal.

 

TAK-438 paura Tono

Ko te puehu TAK-438 (Vonoprazan fumarate ko Vonoprazan ranei) he rongoa hou mo te whakaora i nga mate e pa ana ki te waikawa me te tikanga mahi e kiia ana he poraka waikawa potassium-whakataetae (P-CABs) e aukati ana i te here o nga katote pāhare pāporo ki te H +, K + - ATPase (e mohiotia ana ko te papu proton) i te waahanga whakamutunga o te waikawa waikawa haumanu i nga waahanga parietal puku. Kua whakaaetia te rongoa i Hapani mo te rongoa i nga mate e pa ana ki te waikawa, tae atu ki te kaahi kukuti, te kaokao duodenal, te rehu esophagitis me te hono atu ki te Helicobacter pylori whakakorenga i te keehi o te Helicobacter pylori gastritis.

 

TAK-438 paura Paanga me nga Whakatupato

Ko nga paanga o te taha e pa ana:

▪ korere,

▪ whakapairuaki me te ruaki,

▪ kōroke,

▪ mamae puku,

▪ pupuhi kiri,

▪ Pouri.

 

Ehara ko enei katoa nga paanga kino o TAK438. Mo etahi atu korero, paatai ​​ki to taakuta, ki te kaimuku ranei. Karangahia to taakuta mo nga tohutohu hauora mo nga paanga o te taha. Ka ripoatahia pea e koe nga paanga kino ki a FDA i te 1-800-FDA-1088.

 

tohutoro

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Discovery of he takawaenga pyrrole hou 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 paura) hei potassium-whakataetae aukati waikawa (P-CAB). J Med Chem. 2012 Mei 10; 55 (9): 4446-56. mahi: 10.1021 / jm300318t. Epub 2012 Aperira 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Te tirotiro-nui i nga kaitarai waikawa potassium-whakataetae. J Mata Biomol. 2012 Pepuere; 17 (2): 177-82. mahi: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. He tohu mo te poraka waikawa potassium-whakataetae o te H gastric, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 paura). J Pharmacol Exp Ther. 2011 Whiringa; 339 (2): 412-20. mahi: 10.1124 / jpet.111.185314. Epub 2011 Akuhata 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. He rangahau e whakataurite ana i te painga antisecretory o te puehu TAK-438, he poraka waikawa potassium-whakataetae hou, me te lansoprazole i roto i nga kararehe. J Pharmacol Exp Ther. 2011 Jun; 337 (3): 797-804. mahi: 10.1124 / jpet.111.179556. Epub 2011 Maehe 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. He rangahau whakataurite mo nga momo mahi o te puehu TAK-438, he aukati waikawa potassium-whakataetae hou, me te lansoprazole i roto i nga repe kopu o te koni tuatahi. Biochem Pharmacol. 2011 Mei 1; 81 (9): 1145-51. mahi: 10.1016 / j.bcp.2011.02.009. Epub 2011 Maehe 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 paura), he pakiwaitara waikawa potassium-whakataetae kaha mo te whakaora i nga mate e pa ana ki te waikawa. J Pharmacol Exp Ther. 2010 Oketopa; 335 (1): 231-8. mahi: 10.1124 / jpet.110.170274. Epub 2010 Hurae 12. PubMed PMID: 20624992.