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Nicotinamide riboside karawaka

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Kohinga Rauemi: 1kg / putea, 25kg / pahu

Whakaahuatanga Hua

Tikanga Matua

ingoa hua Nicotinamide riboside karawaka
CAS Tau 23111-00-4
Tātai rāpoi C11H15ClN2O5
Taumaha Taumaha 290.7
Ngā Synonyms 23111-00-4

Nicotinamide riboside karawaka

Nicotinamide riboside (pūhaumāota)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

Nicotinamide ribose pūhaumāota

ahua paura White
Te tiaki me te mahi 0 - 4 C mo te wa poto (nga ra ki nga wiki), -20 C ranei mo te wa roa (marama).

 

Nicotinamide riboside chloride Whakaahuatanga

Ko te Nicotinamide Riboside Chloride (NIAGEN) te momo tote chloride o te nikotinamide riboside (NR). Ko te NR tetahi momo pyridine-nucleoside hou o te huaora B3 e mahi ana hei tomua ki te nikotinamide adenine dinucleotide (NAD) ko NAD + ranei. (GRAS) i te United States hei whakamahi i nga hua kai. Ko te Nikotinamide riboside chloride he ahua karaihe o te Nicotinamide riboside (NR) chloride. Ko te Nicotinamide riboside chloride ka whakapiki i nga taumata NAD [+] me te whakahohe i te SIRT1 me te SIRT3, ka mutu ko te whakarei ake i te waikura hāora me te whakamarumaru kia kore ai e puta te mate pukuriki ki te papa-kai Nicotinamide riboside pūhaumāota puehu ka whakamahia hei taapiringa kai.

 

Nicotinamide riboside pūhaumāota Hangarau o te Mahi

Ko te Nicotinamide Riboside Chloride (NIAGEN) te momo tote chloride o te nikotinamide riboside (NR). Ko te NR he momo pyridine-nucleoside o te huaora B3 e mahi ana hei tomua mo te nikotinamide adenine dinucleotide ko NAD + ranei. Ko te NR te aukati i te ngoikoretanga o te taatai ​​i te taha o te pakiaka dorsal pakiaka neurl ex vivo me te whakamarumaru kia kore e rangona e te haruru o te whakarongo o nga kiore ora. Ko te puehu o te ribotide Nicotinamide te aukati i te uaua, neural me te melanocyte kakau puku. Ko te nui ake o te whakaoranga o te uaua i nga kiore kua kitea i muri i te rongoa me te nikotinamide riboside, ka puta ko te whakapae ka pai ake pea te whakaoranga o nga whekau penei i te ate, whatukuhu, me te ngakau. Ka whakaitihia e te ribotide Nicotinamide te toto glucose me te ate momona i roto i te prediabetic me te momo mate huka momo 2 i te aukati i te whanaketanga o te neuropathy mate huka. Panui: Ko te Nikotinamide Riboside chloride he ranunga α / β.

 

Nicotinamide riboside pūhaumāota Taupānga

Ko te paura Nicotinamide riboside chloride kua rēhitatia me te nama CAS 23111‐00‐4 me te nama EC 807‐820‐5. Ko tona ingoa IUPAC ko 1 - [(2R, 3R, 4S, 5R) -3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; pūhaumāota. Ko te ture rāpoi ngota o te nikotinamide riboside pūhaumāota ko C11H15N2O5Cl, me tōna taumaha ngota 290.7 g / mol. Ko te Nicotinamide Riboside Chloride (NIAGEN) te momo tote chloride o te nikotinamide riboside (NR). Ko te NR he momo pyridine-nucleoside hou o te huaora B3 e mahi ana hei tomua ki te nikotinamide adenine dinucleotide (NAD) ko NAD + ranei. Me mate te NAD + ki te mahi i nga wa katoa. Ko nga taumata iti o te NAD + ka raru pea te hauora. Ko te tango i te ribotide nikotinamide hei awhina i te taumata NAD + iti nei.

 

hua o Nicotinamide riboside karawaka

Ko te Nicotinamide riboside Chloride, he kaiwhakauru i mua i te NAD +, ka whakapiki i nga taumata NAD + ka whakahohe i te SIRT1 me te SIRT3. Nicotinamide riboside Ko te puehu Chloride te puna o te huaora B3 (niacin) me te whakamahi i te Nicotinamide riboside Chloride puehu ka taea te whakarei ake i te pungatara waikura, hei tiaki i nga momona o te mate-hinu-nui. Nicotinamide riboside Chloride te whakaheke i te ngoikoretanga o te hinengaro i roto i te tauira kiore transgenic o te mate a Alzheimer.

 

tohutoro

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[2] Bogan KL, Brenner C. waikawa Nicotinic, nikotinamide, me te nikotinamide riboside: he arotake irahiko o te NAD + huaora o mua i te kai totika a te tangata. Annu Rev Nutr. 2008; 28: 115-30. mahi: 10.1146 / annurev.nutr.28.061807.155443. Arotake Pirimia PMID: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. Ko te acetylation pūmua Mitochondrial hei kaikawe-hei-taraiwa, hei kaiarataki whanaketanga mo te penapena ngako: nga tikanga matū me te pūkoro o te whakarereke acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Hakihea; 48 (6): 561-74. mahi: 10.3109 / 10409238.2013.838204. Arotake PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.

[4] Yang Y, Sauve AA. NAD (+) pākia: Bioenergetics, tohu me te whawhe mo te whakaora. Biochim Biophys Acta. 2016 Tihema; 1864 (12): 1787-1800. mahi: 10.1016 / j.bbapap.2016.06.014. Arotake PMID Panui: 27374990.

[5] Rakei AA. NAD + me te huaora B3: mai i te pākia ki te rongoā. J Pharmacol Exp Ther. 2008 Maehe; 324 (3): 883-93. mahi: 10.1124 / jpet.107.120758. Arotake PMID Panui: 18165311.

[6] Kato M, Lin SJ. Te whakaritenga o te NAD + pungao, te waitohu me te wehenga i roto i te rewena Saccharomyces cerevisiae. Tapia DNA (Amst). 2014 Nov; 23: 49-58. doi: 10.1016 / j.dnarep.2014.07.009. Arotake PubMed PMID: 25096760; PubMed Central PMCID: PMC4254062.

[7] Cantó C, et al. Ko te NAD (+) o mua te nikotinamide riboside e whakarei ake i te pungao hāora me te whakamarumaru i te mōmona momona-whaiwhakaaro-nui. Papa Meta. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Ko te Nicotinamide Riboside te Whakaora i te Whakaaotanga Na roto i te Whakatikatika i te Kaihauturu-Kua Whakahohetia te Kaihauturu-γ Kaihono 1α Whakahaerehia te β-Huna 1 Whakakoretanga me te Whakakitenga Genewa Mitochondrial i nga Tauira Kiore o Alzheimer. Te Neurobiol Kaumatua. 2013 Hune; 34 (6): 1581-8.

[9] Collin D Heer, et al. Ko te Coronavirus me te PARP Expression Ka wehewehe i te NAD Metabolome: He Kaainga Ka Kaha Te Mahi mo te Taumaru Kino. bioRxiv. 2020 Apr 30; 2020.04.17.047480.