Comodo SSL Kaihoko IDFP Raw (615250-02-7) hplc pea98% | Tuhinga
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IDFP

IDFP Ko te pūhui organophosphorus e MAGL dually inhibits me FAAH ki IC50 uara o 0.8 ko 3 NM, respectively.1 I 10 mg / kg, faateitei IDFP taumata roro o 2-AG me Aea atu atu 10-kainga, a ka heke taumata o te waikawa arachidonic Tuhinga o mua. Nga endocannabinoids, 2-arachidonoyl nonireka (2-AG) me arachidonoyl ethanolamide (Aea), he biologically lipids kaha e whakahaere mahi neurological me pūkoro kanorau i whakahohe i te mau farii ohipa cannabinoid, cannabinoid pokapū (CB1) me cannabinoid piringa (CB2). Ko te monoacylglycerol lipase (MAGL) me te waikawa waikawa amidehydrolase (FAAH) te waihanga i te 2-AG me te AEA, na te mutunga o te mahi koiora.

Whakaahuatanga Hua

 

Ataata IDFP

 

 


 

I.IDFP Ngā Pūāhua taketake:

 

ingoa: IDFP
CAS: 615250-02-7
Kaupapa Motuhake: C15H32FO2P
Taumaha Taumaha: 294.391
Te Poari Maka:
Tiaki Tārua: -20 ° C
tae:

 


 

II. Huringa IDFP

 

1.Names:

Ingoa Ingoa: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

 

2. Whakamahinga IDFP:

Ko te IDFP he pühui organophosphorus e pä ana ki te sarin kaihoko. Ka rite ki te sarin, ko te IDFP he aukati irreversible mo te maha o nga hauora rerekē e whakamahia ana hei wawahi i nga neurotransmitters, ahakoa he kaha te ngoikore o te waahanga o te IDFP hei aukati o te acetylcholinesterase (AChE), me te IC50 o 6300nM anake, ko reira he inhibitor puai o rua whākōkī monoacylglycerol lipase (MAGL), te pūmua whākōkī tuatahi kawenga mō te ha'iriiri te endocannabinoid 2-arachidonoylglycerol (2-AG), me te fatty waikawa amide hydrolase (FAAH), te pūmua whākōkī tuatahi e tuukino te tahi atu anandamide endocannabinoid matua . Ko te IC50 o IDFP ko 0.8nM i MAGL, me 3.0nM i FAAH. Ko te whakakorenga o enei reeha e rua he nui ake te piki o te aandamide me te 2-AG i roto i te roro, me te whakaatu i te tohu tohu cannabinoid me nga paanga whanonga pukupuku o te kararehe i roto i nga akoranga kararehe, ahakoa te kore o te kaha i te AChE, kaore he tohu tohu cholinergic i whakaputa. [1 ] [2] [3] [4] Ahakoa tona hanganga matakite rite ki nga kaitahu nati kua whakakorehia, ko te roera o te IDFP te roa ka hinga i waho o te whakamaramatanga o "nga mea taiao kawa" i raro i te Hui Whakanoho Weaponui, [5] me mai mai kaore hoki i te whakaatu i te hanganga AChE kaha o nga komophosphorus e hāngai ana, kaore te kaupapa IDFP e whai mana ki nga mana ture.

3.He aha te momo o IDFP?

Mo te rokiroki mo te wa roa, e whakaaro ana matou kia penapena te IDFP kia rite ki to -20 ℃. Me noho kia kotahi tau te roa.
Ka tukuna te IDFP hei whakautu i te acetate methyl. Hei whakakore i te wairewa, ka whakakore i te konupae methyl i raro i te ngawari o te hauota me te whakawhānui i te whakarewa o te whiringa. Ko nga waihanga pēnei i te waihanana, DMSO, me te dimethyl formamide kua oti te horoi ki te ipu inerua ka taea te whakamahi. Ko te ngoikore o te IDFP i roto i enei whakarewa ko te 10mg / ml.
Mena kei te hiahiatia nga rongoa waahi mo nga whakamatautau koiora, ka taea te pai kia rite ki te dilu i te waikawa o te wairewa ki roto i te kapi me te saline koreotonic.Whakaarohia he iti noa te toenga o te waipiro, no te mea ka whai hua ngaohanga o te waihanga i nga wahanga iti. kaore i te tūtohu kia tohua te otinga waipiro mo te ra kotahi.

4.How kei te mahi te IDFP?

Ko te IDFP he aukati e kore e taea te whakawhiti mo te maha o nga reheatanga rereke e whakamahia ana hei wawahi i nga neurotransmitters, ahakoa he kaha te ngohe o te IDFP hei kaitautuhi o te acetylcholinesterase (AChE), ahakoa he kaha te aukati o te piti o te hauora monoacylglycerol lipase ( MAGL), ko te rezyme tuatahi hei kawenga i te mutunga o te 2-arachidonoylglycerol endocannabinoid (2-AG), me te waikawa fatty amide hydrolase (FAAH), te rezy tuatahi e whakaiti i te atu anandamide mainendocannabinoid. He pūhui organophosphorus e MAGL dually inhibits me FAAH ki IC50 uara o 0.8 ko 3 NM, respectively.1 I 10 mg / kg, faateitei IDFP taumata roro o 2-AG me Aea atu atu 10-kainga, a ka heke taumata o te waikawa arachidonic e 10-nui.

 

5.Warning:

Ehara tenei hua mo te whakamahi tangata, mo te kararehe ranei, kei te rangahau tonu ano te whakatupato. Kati i te whakapiri tika ki te kiri, ki nga kanohi, ki te waahanga rewharewha, ki tetahi raruraru, karanga tonu atu ki to taote.

 

6.IDFP Puri Rawa:

Min tono 10grams.
Ko te uiuinga mo te nui noa (I roto i te 1kg) ka taea te tukuna i nga haora 12 i muri i te utu.
Ka taea te tuku atu i te raupapa nui i roto i nga ra mahi 3 i muri i te utu.

 

7.IDFP Raw Powder Recipes:

Ki te uiui i to tatou Kiritaki Tauhokohoko (TKT) mo nga taipitopito, mo to korero.

 

8.IDFP Marketing:

Kia whakaratohia i roto i te heke mai.

 

9.Does IDFP He Nga Paanga Tae?

Ko te whakawhitinga tawhito, he whakaaro nui mo te whakaritenga o te tote me te wai me te mana o te totohu-roa-roa, kei te whakanuihia i te anandamide me te rua o ona hauora whakawhitinga nui, te cyclooxygenase-2 (COX-2) me te waikawa okawa waikawa (FAAH) . Ko te whaowhia o te aranamide (15, 30, me te 60 nmol · min-1 · kg-1) i roto i te whakawhitinga whakawhitinga o C57BL / 6J kiore i whakaihiihi i te diuresis me te tote tote i roto i te COX-2- engari ehara i te tikanga COX-1. Hei whakatau i te mutunga o te endocannabinoids i roto i te medulin real e taea te whakaputa i nga hua rite, nga painga o te isopropyl dodecyl fluorophosphate (IDFP), he mea karai i nga piti-endocannabinoid hydrolases, i akohia. Ko te maimoatanga IDFP i piki ake te tere o te hanganga urine me te konupaera konutai i roto i te COX-2- engari ehara i te tikanga COX-1. Kaore hoki te kaitautoko me te IDFP i pa ki te tauera o te whakamahinga o te ao. E kore nahanaha (0.625 mg · kg-1 · 30 min-1 iv) e kore intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) IDFP pretreatment i mua i anandamide intramedullary (15-30 nmol · min-1 · kg-1) nga hua o te aukamide kaore i pangia, e whakaaro ana ehara i te mea ko te waihanga o te rewharewha he mea e tika ana mo tona hua o te diuretic. Ko te IDFP o te Intramedullary kahore he kaha ki te rere o te toto kaore i te whakaheke i te rere o te toto. Ko nga paanga o te IDFP mo te rere o te rere a te urine me te rere o te toto totohe ko te FAAH-ka whakawhirinaki ki te whakamahi i nga kiore knockout FAAH. Tātaritanga o ngä nohanga kiore PGE2 mimi i HPLC-electrospray ionization taupiri spectrometry papatipu whakakitea e heke IDFP maimoatanga PGE2 mimi e hāngai ki te tūranga o FAAH me anandamide endogenous mahi i roto i te metabolite Cox-2-ti'aturi ki te whakahaere i diuresis me te tote papī i roto i te enei raraunga mousekidney.

 


 

III. IDNP HNMR

 

Ko tatou te Pupuhi o te paura, te paru Aprepitant mo te hoko, te Raw Aprepitant powder (170729-80-3) hplc≥98% | Rangahau R & D AASraw

 


 

IV. Me pehea te hoko IDFP mai AASraw?

 

1.Me whakapiri mai ki a maatau i ta maatau īmērapūnaha uiuinga, te rangiperangi raneikaihoko ratonga kiritaki (TKT).
2.Me homai ki a matou to nui me to korero.
Ka hoatu e 3.Our TKT ki a koe te korero, te wa utu, te tau aroturuki, nga huarahi tuku, me te raketanga o te taenga mai (ETA).
4.Pairanga ka mahia, ka tukuna atu nga taonga i nga haora 12 (Mo te ota i roto i te 10kg).
5.Goods i whakawhiwhia me te tuku korero.

 


 

Whakaarohia tō rangitaki hua pai:

 

 Te wahine Viagra? Ko nga mea katoa e pa ana ki te Sex Whakapai ake i te puehu Flibanserin Me pehea te whakamahi Clenbuterol mo te mate taimaha He aha te paura nandrolone e whakamahia ana mo nga painga / nandrolone?

 


 

He taipitopito atu mo nga hua e whai hua ana,uru mai ki te panui i konei.


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