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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder Ko te piperazinyl phenylurea te ahua o te hanganga mai i te alkyl carbamates me nga pūhui heterocyclic alpha-keto, a ko te kaitautoko kaha me te kōwhiringa o te waikawa fatty acide hydrolase (FAAH) (IC50s = 34 me 33 nM i roto i te kiore me te tangata, ia) e kaha ana ki te whiti i te blood-brain barrier.1 I te 20 mg / kg, ka honohono ki te pae o FAAH i te tuhi o te mahi urutare e whakaputa ana i te aniline me te FAAH-poperazinyl carbamate.

Aarua AASRAW PDF Ataata

Whakaahuatanga Hua

 

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

 

ingoa: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Pure: ≥99% (HPLC)
taurite: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Kaupapa Motuhake: C19H19N5OS
Taumaha Taumaha: 365.459
Te tau whakarewa: 240.48
Tauranga kohua: 559.69 ° C i 760 mmHg
kiato: ~ 1.3 g / cm3
Tiaki Tārua: Tiakina i + 4 ° C
Haupae: DMSO: ≥28mg / mL
Taurangi tohu: N20D 1.68
tae: He uaua tio
INCHI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
KAUPAPA KI: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Te whakamahinga o te paura i te huringa:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid paura, JNJ 166101 Powder

2.How is the work on N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Whakamahinga Powder?

Ko te FAAH te whakakotahi i te JNJ-1661010 e whakaatu ana i te hokinga tere o te whakawhitiwhitinga i waenganui i te JNJ1661010 me te pae hohe, e whakaterehia ana i nga teitei ake. Ko JNJ-1661010 he taraiwa, he mea whakarewahia e te LC-ESI-MS. Ko nga taakahu JNJ-1661010 me te phenylthiadiazole i roto i te taiao hydrophobic me te phenylurea i roto i te putea hydrophilic o FAAH, JNJ-1661010 (20 mg / kg ip) ka whakakore i te FAAH i te iti rawa 85% mo te 4 h i muri i te dosing, te kohikohi hua o te ngutu ethanolamides i roto i te roro roro rat. Ko te horopaki JNJ-1661010-ka whakahurihia i te waahanga o te waahanga taiao me te kaha teitei o te 90% i te 30 min ka whakairihia i roto i te Mild Thermal Injury (MTI) me te tauira kiore. Ko te JNJ-1661010 (20 mg / kg) ka huri i te taiao taiao i te 60.8% i te 30 min i roto i te koiora o te raima i te taatai. Ko te JNJ-1661010 (50 mg / kg ip) e whakaatu ana i te whakahekenga nui o te hiperalgeia i te 30 min ka whakatairanga i te tauira whara a te kiore o te mamae o te inflammatory.
Ko nga Rats kua tae ki te JNJ-1661010 (20 mg / kg ip) he Cmax CMAX o 26.9 μM i te Tmax o 0.75 h me te Cmax i te roro o 6.04 μM i te Tmax o 2 h. JNJ-1661010 (20 mg / kg ip) ka whakakore i te roro FAAH ka whakanui i te taumata AEA i roto i te roro i roto i te kiore.

3.Warning on N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid paura

4.Ko nga tohutohu:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min tono 10grams.
Ko te uiuinga mo te nui noa (I roto i te 1kg) ka taea te tukuna i nga haora 12 i muri i te utu.
Mo te tono nui (I roto i te 1kg) ka taea te tukuna ki roto i nga waa mahi 3 i muri i te utu.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Mahinga Kaikawa:

Ki te uiui i to tatou Kiritaki Tauhokohoko (TKT) mo nga taipitopito, mo to korero.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid paura Te hokohoko:

Kia whakaratohia i roto i te heke mai.

 


 

III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide paura HNMR

 

Ko tatou te Pupuhi o te paura, te paru Aprepitant mo te hoko, te Raw Aprepitant powder (170729-80-3) hplc≥98% | Rangahau R & D AASraw

 


 

IV. Me pehea te hoko N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide paura mai i AASraw?

 

1.Me whakapiri mai ki a maatau i ta maatau īmērapūnaha uiuinga, te rangiperangi raneikaihoko ratonga kiritaki (TKT).
2.Me homai ki a matou to nui me to korero.
Ka hoatu e 3.Our TKT ki a koe te korero, te wa utu, te tau aroturuki, nga huarahi tuku, me te raketanga o te taenga mai (ETA).
4.Pairanga ka mahia, ka tukuna atu nga taonga i nga haora 12 (Mo te ota i roto i te 10kg).
5.Goods i whakawhiwhia me te tuku korero.

 


 

Whakaarohia tō rangitaki hua pai:

 

 Te wahine Viagra? Ko nga mea katoa e pa ana ki te Sex Whakapai ake i te puehu Flibanserin Me pehea te whakamahi Clenbuterol mo te mate taimaha He aha te paura nandrolone e whakamahia ana mo nga painga / nandrolone?

 


 

He taipitopito atu mo nga hua e whai hua ana,uru mai ki te panui i konei.


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